Effects of vitamin A and vitamin A acid on eicosanoids induced in rat lung tissue treated with endotoxin.
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概要
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Slice tissues of rat lung were preincubated with vitamin A (VA) or vitamin A acid (VAA) and then incubated with endotoxin. After the reaction, the amount of LTC<SUB>4</SUB>, LTB<SUB>4</SUB> and 6-KPGF<SUB>1α</SUB> in the reactive solution were analysed quantitatively by RIA following the method of Salali or Powell et al. TLC<SUB>4</SUB> was significantly suppressed by 10<SUP>-6</SUP>M VA. And 10<SUP>-8</SUP>M VA still showed this suppression. The induction of LTB<SUB>4</SUB> was also suppressed significantly by 10<SUP>-7</SUP>M VA. VAA suppressed the induction of LTC<SUB>4</SUB> significantly at the concentration from 10<SUP>-7</SUP>M to 10<SUP>-9</SUP>M. And 10<SUP>-8</SUP>M VAA showed the most significant suppression. The induction of LTB<SUP>4</SUP> was also suppressed significantly by 10<SUP>-9</SUP>M VAA but was accelated by 10<SUP>-7</SUP>M. However VAA did not interfere the synthesis of 6-KPGF<SUB>1α</SUB>. The values of LTB<SUB>4</SUB> and LTC<SUB>4</SUB> determined by RIA were confirmed by the combined method of HPLC and RIA. These suggest that VA and VAA will suppress the synthesis of lipoxygenase products specifically <I>in vitro</I> experiment as well as <I>in vivo</I> experiment already shown in the former report.
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