Relationship between vitamin E and T-kininogen.

概要

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It is experimentally know that vitamin E enhances both humoral immune response and protection against micro-organism infection, but the mechanism has not been clarified. On the other hand, T-kininogen, a kinin precursor, cysteine proteinase inhibitor, and acute phase protein, is suggested to be induced by activation of macrophages. In order to clarify the action of vitamin E on the immune response, we investigated the relationship between vitamin E and T-kininogen in rat. T-kininogen level in rat serum was determined by single radial im-munodiffusion using specific antiserum against T-kininogen. Vitamin E provides a potent stimulus in vivo for the production of T-kininogen, such as seen in lipopolysaccharide (LPS) administration. Namely, T-kininogen level in rat serum, that was given intraperitoneal injection of vitamin E for six days ranging from 1.5 mg to 25 mg per day, increased from 758±218 to 3, 220±263, μg protein/ml with an increase of vitamin E level in the serum (12.9±1.1 to 38.8±6.2μg/ml) . Whereas normal and vehicle (polyethylene 60-hydrogenated castor oil) -received rats were 452 ± 77 to 483 ± 82 μg/ml of T-kininogen and 7.4±0.7 to 7.2±0.9 μg/ml of vitamin E. In addition, vitamin E enhanced induction of T-kininogen by LPS administration. From these results, the pharmacological action of vitamin E on the immune response was discussed.
日本炎症・再生医学会の論文