The effect of ketotifen on density distribution of eosinophils in patients with atopic dermatitis.

概要

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Density analysis and ultrastructural observation were performed on eosinophils from patients with atopic dermatitis (AD) . Before treatment, density analysis displayed lower peak density and greater number of hypodense eosinophils compared with normal subjects. After treatment with ketotifen, profiles demonstrated similar peak density to normal subjects following decreased number of hypodense eosinophils which was directly proportional to remission of clinical symptoms. Hypodense eosinophils were morphologically characterized by partial or complete degranulation. It is suggested that hypodense eosinophils may contribute clinical manifestation of AD and that ketotifen may give clinical remission for patients with AD by decreasing such cells.
日本炎症・再生医学会の論文