Effect of PAF on chemical mediator release from passively sensitized guinea pig lung tissue.
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概要
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The role of PAF as a chemical mediator has not been fully elucidated. In the present investigation, we examined the effect of PAF on the anaphylactic release of histamine, SRS-A and LTC<SUB>4</SUB> in passively sensitized guinea-pig lung tissue.<BR>Male guinea-pigs were killed. The lungs were removed, minced and rinced by Krebs-Henseleit solution. The minced lung tissues were passively sensitized by incubating with γ-globulin. Then the sensitized lung tissues were challenged by ovalbumin. Histamine and SRS-A were assayed by tissue bioassay system. LTC<SUB>4</SUB> was assayed by radioimmunoassay method.<BR>It is concluded that PAF increases the release of histamine and SRS-A from passively sensitized guineapig lung tissue by the antigen challenge. In the same way, PAF increases the release of LTC<SUB>4</SUB>.
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