Clinical observation of infections in primary functional disorders of neutrophils and monocytes.

概要

論文の詳細を見る
Clinical features of infections were observed in various types of primary functional disorders of neutrophils and monocytes in childhood. The patients included 5 with congenital neutropenia, 4 with lazy-leukocyte syndrome, 8 with hyper-IgE syndrome, 2 with defective neutrophil chemotaxis with hyper-IgM, 1 with Shwachman syndrome, 2 with Chédiak-Higashi syndrome, 1 with Strauss type of neutrophil dysfunction, and 4 with monocyte dysfunctions. Respiratory tract infections, purulent lymphadenitis, superficial abscesses, and otitis media were frequent in all types of the neutrophil disorders, and candidiasis was the most prominent infection in the monocyte disorders. It was noted that gingivitis was almost persistent and aphthous stomatitis was recurrent in congenital neutropenia and superficial abscess was the most frequent infection in hyper-IgE syndrome. <I>Staphylococcus aureus</I> constituted 55.0% of the pathogenic microorganisms cultured from the throat or pus samples. Gram-negative bacteria and fungi were also cultured from the infected sites. The knowledge of such clinical features of infections provides some useful information for the appropriate treatment of infections in primary functional disorders of neutrophils and monocytes.
日本炎症・再生医学会の論文