FACSTAR analysis on effects of immunotherapeulic agents : Bredinin, Cyclosporin A, and Picibanil therapy in BALB/cmice.:<I>Bredinin, Cyclosporin A, and Picibanil therapy in BALB/c mice</I>

概要

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Bredinin (BRD) and Cyclosporin A (CyA) as immunosuppressants, and Picibanil (OK432) as immunostimulant, had different effects on T, B cells, and macrophages respectively. The drugs had different influence on the spleen cell count, when single cell suspension was made. FACSTAR analysis requires hemolysis procedure prior to run the equipment. Cell count of the single cell suspension had remarkable decrease after hemolysis procedure. The drugs decreased cell count in different degree respectively. BRD decreased the number of pan B cells, CyA decreased that of L3T4 (helper T), and OK432 increased that of Lyt 2 (suppressor/killer T) . It was difficult to evaluate effects of the drugs in the whole body level. Since less than half amount of cells was able to be analyzed by FACSTAR. It remains to be disclosed how the FACSTAR data reflects changes of immune responsive cell number in the whole body level.
日本炎症・再生医学会の論文