Macrophage activation in vivo and inhibition of heat-induced hemolysis by anti-inflammatory substance, Aloctin A.

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Morphology and lysosomal enzyme activity were tested in peritoneal macrophage cultures after stimulation <I>in vivo</I> with anti-inflammatory substance, Aloctin A (Alo A), and compared to the same parameters in normal peritoneal macrophages. Alo A-stimulated macrophages were more adhesive and more spread out than non-treated macrophages. The intracellular level of β-glucuronidase activity of macrophages was markedly increased after stimulation with Alo A, while the extracellular level of β-glucuronidase activity was not significantly different from normal macrophages. We also studies the effect of Alo A on heat-induced hemolysis. Alo A markedly inhibited it. The mechanism of the anti-inflammatory properties of Alo A was discussed.
日本炎症・再生医学会の論文