Involvement of reactive oxygen species in contact photosensitization in mice.

概要

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To investigate the possible participation of reactive oxygen species (ROS) in the contact photosensitization process, mice were treated with long-acting liposomal-superoxide dismutase [L-SOD] before photosensitization. Photosensitization to 3, 3', 4', 5-tetrachlorosalicy-lanilide (TCSA) was significantly suppressed by the pretreatment of mice with L-SOD. This suppression was not mediated by suppressor cells or due to an unresponsive state produced by the use of L-SOD. Rather, the suppression appeared to be due to the failure of production of photoallergen. L-SOD treatment induced the suppression of contact photosensitivity (CPS) to TCSA but not ordinary contact sensitivity (CS) to TCSA or dinitrofluorobenzene (DNFB), suggesting that the production of photoallergen is more critically dependent on the presence of ROS than that of ordinary contact allergen. The results provide evidence that ROS are produced by light absorption in the presence of oxygen and react with the biological substrate to form photoallergens.
日本炎症・再生医学会の論文