Effects of prostaglandins on O production of human polymorphonuclear leucocytes (PMN).
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概要
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The effects of various kinds of prostaglandins on O<SUP>-/⋅</SUP><SUB>2</SUB> production of human PMN stimulated by opsonized zymosan were studied <I>in vitro</I> by a cytochrome C reduction method. O<SUP>-/⋅</SUP><SUB>2</SUB> production of PMN was inhibited by a 0.02μg/m<I>l</I> solusion of PGE<SUB>1</SUB> and a 0.2μg/m<I>l</I> solusion of PGE<SUB>2</SUB> up to 40% of that of the untreated cells. On the other hand, PGD<SUB>2</SUB>, PGI<SUB>2</SUB>, PGF<SUB>2α</SUB> did not inhibit the O<SUP>-/⋅</SUP><SUB>2</SUB> production at a concentration of 0.2μg/m<I>l</I>. Antibody dependent cell mediated cytotoxicity (ADCC) of PMN was also inhibited by both PGE<SUB>1</SUB> and E<SUB>2</SUB> at a concentration of 0.2μg/m<I>l</I> up to 50% of cytotoxicity of the untreated cells. The reduction pattern of O<SUP>-/⋅</SUP><SUB>2</SUB> production from PMN by treatment with various prostaglandins was not parallel to the increase pattern of cytoplasmic cyclic AMP levels in the similarly treated PMN.
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