<I>Release of slow reacting substance (SRS) from ocular tissues in the guinea pig</I>

概要

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Ca ionophore A 23187 (A 23187) -or antigen-induced release of slow reacting substance (SRS) from passively sensitized ocular tissues or from ocular tissues of non-sensitized or actively sensitized guinea pigs was investigated. In non-sensitized guinea pigs, considerable amount of SRS was generated in choroid>conjunctiva>ciliary body, in this order, by A23187. However, the release from iris was negligible, and no release was observed in retina and cornea. In actively sensitized guinea pigs, similar results of the SRS release by specific antigen or A23187 were obtained from each ocular tissue in the same order as the A23187-non-sensitized tissue experiments. Furthermore, when choroid, ciliary body and iris tissue were sensitized passively by injecting antiserum of the guinea pig in vitereous humor and challenged by antigen, large amount of SRS was released from the choroid and ciliary body, less extent from the iris. The ileal contraction of guinea pig induced those SRS was almost completely inhibited by SRS-specific antagonist, FPL 55712. Although we failed to determine the types of leukotriene of the SRS released by chromatography because of very small amount of the tissue employed, it was suggested that SRS plays a role in inflammation or allergy of the uvea.
日本炎症・再生医学会の論文