<I>Effect of acid on gastric mucosal prostaglandins and gastric protection in rat</I>
スポンサーリンク
概要
- 論文の詳細を見る
The effect of hydrochloric acid, tetragastrin, and cimetidine, a H<SUB>2</SUB>-receptor antagonist, on endogenous prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>) and prostacyclin (PGI<SUB>2</SUB>) in rat gastric mucosa was investigated. Intragastric instillation of 0.25 N HCl increased PGE<SUB>2</SUB>by about 2 times in both fundic and antral mucosa, and inhibited ulcer formation induced by subsequent instillation of a necrotizing agent (0.6 N HCl) . Tetragastrin (4 μg/kg, subcutaneously) also increased PGE<SUB>2</SUB>and PGI<SUB>2</SUB>in both fundic and antral mucosa 15 minutes after administration, and also inhibited ulcer formation induced by subsequent instillation of 0.6 N HCl. Cimetidine in a non-antisecretory dose (2 mg/kg, intraperitoneally) exerted no effect on endogenous PGE<SUB>2</SUB>, while in an antisecretory dose (100 mg/kg), the agent decreased PGE<SUB>2</SUB>by 72% in fundic and 84% in antral mucosa. These results suggest that acid induces those cytoprotective PGs and enhances mucosal integrity.
- 日本炎症・再生医学会の論文
日本炎症・再生医学会 | 論文
- 新規キノリノン誘導体TA-270の炎症性気道疾患に対する効果
- Salazosulphapyridine, Predonizolone の好中球機能に及ぼす影響と Sodium ferrous citrate との併用効果についての検討
- Sodium ferrous citrate の好中球機能に及ぼす影響
- Mesalazine(Pentasa) の好中球機能に及ぼす影響と Sodium ferrous citrate(SFC) との併用効果についての検討
- 非ウイルスベクターによる細胞標的法の開発