<I>Studies on the correlation between autoimmunological phenomena and coagulation/fibrinolytic reactions in systemic lupus erythematosus</I>

概要

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In order to clarify the correlation between autoimmunological phenomena and coagulation/fibrinolytic reactions in systemic lupus erythematosus (SLE), coagulation/fibrinolytic functions were studied in 20 patients with SLE; 9 of whom were in active stage and 11 were in inactive stage. And in one of them serial changes of autoimmunological reactions and coagulation/fibrinolytic reactions were observed for about 2.5 years until today from the onset of SLE. The results obtained were as follows : 1) Significant increase of plasma β-thromboglobulin level and significant decrease of plasma plasminogen and antithrombin III (AT-III) levels were observed in active SLE compared with those in inactive SLE. 2) There was a significant positive correlation (r=0.77) between serum CH50 and plsma AT-III levels in 20 cases with SLE. And in one of them CH50 and AT-III changed in parallel with each other. 3) Plasma von Willebrand factor activity (FVIIIR: WF) level was mildly higher in active SLE than that in inactive SLE. And in one case with SLE FVIIIR: WF changed in opposition to CH50 and AT-III. These results indicate that disease activity, vasculitis and hypercoagulability of blood may be intensely related to one another in SLE, that is, in parallel to the disease activity thrombogenesis may be accelerated.
日本炎症・再生医学会の論文