<I>Platelet aggregation in Behcet's disease</I>

概要

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Vascular changes in Behçet's disease are important in not only vasculo-Behçet's disease, but also the most cases. Thrombo-phlebitis of cutaneous vein frequently and that of deep vein occasionally are found. We experienced two cases of Behçet's disease with hyperplatelet aggregation. In the first case, we observed multiple thrombosis of deep vein including vena cava and subclavia. The second patient was admitted because of cerebro-vascular disorders. The platelet aggregation induced by ADP markedly increased in both cases. We also observed a tendency of hyperplatelet aggregation in another 9 cases of Behçet's disease. We used fenbufen and dipyridamole, anti-thrombocytic drugs to our patient. The hyper-aggregation decreased and turned almost normal after the treatment. Thus, we think that the use of anti-thrombocytic drugs may benefit certain patients with Behçet's disease by inhibiting thrombostic events.
日本炎症・再生医学会の論文