<I>Modulation of in vitro immunoglobulin production by prostaglandins</I>
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概要
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This study showed the affection of prostaglandins (PG) on the <I>in vitro</I> IgG, IgM production by pokeweed mitogen stimulated normal human peripheral blood lymphocytes. Concentrations of PGE<SUB>1</SUB> and PGA<SUB>1</SUB> in excess of 10<SUP>-6</SUP> M were suppressive. PGE<SUB>2</SUB> and PGs of the F series were less suppressive and significant suppression was seen in concentrations greater than 10<SUP>-5</SUP> M. Indomethacin added to cell cultures did not enhance Ig production. This discrepancy between physiologic concentrations and the very large pharmacologic concentration necessary to suppress Ig synthesis <I>in vitro</I> makes the physiologic role of PG in the modulation of Ig synthesis questionable.
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