Clinical study of 20 cases of pediatric allergic (eosinophilic) cystitis.

概要

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Twenty pediatric cases of aseptic chronic cystitis due to allergy are presented. In 6 of these, eosinophilic inflammation was histologically confirmed, however the remaining cases also seemed to have similar causative factors. The average age of these patients was 7.1 years (male: 14 cases, female: 6 cases), and gross hematuria and bladder irritation were prominent and more severe than in common bacterial cystitis. Practically almost all of the patients had allergic disorders, and 17 cases had eosinophilia, while elevation of serum IgE was detected in 10 cases. Endoscopically, the lesions were classified into 2 groupes: one was diffuse congestion with edema of the mucosa, and the other was granulomatous lesions similar to botryoid sarcoma. Biopsy specimens obtained from 6 cases of each lesion type showed infiltration of eosinophilic cells into the submucosa and muscular layers with congestion and edema of the mucosa. All of the patients improved without steroid administration or surgical intervention, within only 4 weeks of hospitalization free from certain allergens. In follow-up studies, recurrences have not been experienced with the exception of two cases.<BR>This result show that eosinophilic cystitis in children should be considered as a temporary reaction to some category of allergens, from which the patients should simply be kept free without any special urological management.
日本炎症・再生医学会の論文