Nurse-like cells play an important role in joint destruction of rheumatoid arthritis.

概要

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We reported the abnormalities in bone marrow of rheumatoid arthritis (RA) patients. Lymphocytes and myeloid lineage cells increased in hematopoietic bone marrow of RA patients. The objective of this study is to investigate the bone marrow stromal cells established from RA patients and the role of stromal cells in joint destruction in RA. In the present study, we established nurse-like stromal cell (RA-BMNC) lines from bone marrow of RA patients. They were defined as nurse cells because of pseudoemperipolesis activity that allowed lymphocytes to migrate under-neath. The RA-BMNCs were observed to have many characteristics similar to that of nurse like stromal cells established from synovial tissues of patients with RA. RA-BMNC produced multiple inflammatory cytokines and hyaluronan (HA) . RA-BMNC produced significantly higher levels of IL-6, -8, and GM-CSF when coculture with lymphocytes. The cells also produced IL-1β, G-CSF and TNFα only when cocultured with lymphocytes. HA production by RA-BMNC was correlated with pseudoemperipolesis activity. RA-BMNC also plays an important role in the differentiation of myeloid lineage cells. These results indicate that RA-BMNC may play a pivotal role in the joint destruction of RA.
日本炎症・再生医学会の論文