The effects of recombinant human bone morphogenetic protein-2(rhBMP-2) on periodontal tissues.

概要

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In order to clarify whether bone morphogenetic protein (BMP) was effective and useful in periodontal regenerative therapy, three experiments were performed.<BR>(1) Recombinant human BMP-2 (rhBMP-2) was applied in the horizontal alveolar bone defects of beagle dogs. The carrier was complex of gelatin and polylactic acid polyglycolic acid copolymer. The carrier without rhBMP-2 was used as a control. Twelve weeks later, animals were sacrificed and histological observations were performed. Substantial amount of new bone, cementum, and periodontal ligament were regenerated in the rhBMP-2 group. In the control group, little periodontal regeneration was observed.<BR>(2) rhBMP-2 was implanted with three types of ceramic carriers (biphasic calcium phosphate, β-tricalcium phosphate, and hydroxyapatite) under the rat dorsal skin. In the BCP-BMP group, bone like tissue was formed in all 4 rats, and new bone tissue forming lamellae was observed in 2 of the 4 rats. The amounts of new bone were relatively smaller in the TCP-BMP and HAP-BMP groups. No bone like tissue was observed in any rats in the control groups.<BR>(3) Although 500 ng/ml rhBMP-2 were added to the culture wells of human periodontal ligaments' cells, no elevation of ALP activity of the cells was observed.<BR>These results suggest that rhBMP-2 will be a beneficial material in periodontal regenerative therapy.
日本炎症・再生医学会の論文