Detection of type C retroviral particles in the lung cells of a patient with systemic lupus erythematosus.

概要

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Novel type C retroviral particles were detected in the bronchoalveolar lavage fluid (BALF) of a patient who had systemic lupus erythematosus (SLE) with interstitial pneumonia. Syncytial cell formation in the BALF and positive reverse transcriptase activity in the supernatant of the cultured cells were observed. No antibody to known human retroviruses or proviral sequences was detected.<BR>Serum antibody to this putative type C retrovirus was also detected in 23.5 % of SLE patients and 26.9 % of idiopathic pulmonary fibrosis patients. This novel type C retroviral particle could be one of the pathogenic agents for SLE or interstitial pneumonia.
日本炎症・再生医学会の論文