Quality of arthritis: Early articular lesions in experimental animal models for arthritis.:<I>Early articular lesions in experimental animal models for arthritis</I>
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Early articular lesions were studied in four experimental animal models as follows; adjuvant arthritis in F344 rats, type II collagen-induced arthritis in DBA/1J mice, spontaneous arthritis in MRL/Mp-lpr/lpr (MRL/1) mice, and pristane-induced arthritis in DBA/1J mice.<BR>Adjuvant arthritis: Acute inflammatory lesions started to develop 6 hours after elicitation. Chronic inflammatory lesions started to develop 3 days after elicitation.<BR>Type II collagen-induced arthritis: Acute inflammatory lesions were started to appear by 6 hours and were seen dominant by 2 weeks after elicitation. Then the lesions started to diminish, and were replaced by chronic inflammation at 4 weeks.<BR>MRL/1 mouse polyarthritis : Histopathological findings of the articular lesions started to develop by 6 weeks of age. Acute and chronic inflammation started at the same time.<BR>Pristane-induced arthritis : IgG and IgM rheumatoid factor start to elevate their titer by 3 weeks and 6 weeks after elicitation, respectively. Joints lesions were noticed under microscope by 14 weeks. Acute and chronic inflammation were seen simultaneously.<BR>Acute inflammation preceded chronic lesion in adjuvant arthritis and type II collagen-induced arthritis. Acute and chronic inflammation was seen simultaneously in MRL/1 mouse polyarthritis and pristane-induced arthritis. Immunological abnormalities preceded articular lesions in MRL/1 mouse polyarthritis and pristane-induced arthritis. Joint lesions preceded elevation of anti-type II collagen antibody in DBA/1J mice. Scientists have to pay much attention on differences in quality of arthritis in experimental animal models.
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