Concentrations of Voltaren (diclofenac sodium) SR capsule in serum and tissues of patients with rheumatoid arthritis.
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概要
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Concentrations of diclofenac in serum and tissues were studied after single oral administration of Voltaren SR capsule in patients with rheumatoid arthritis.<BR>Samples of blood, synovial fluid, synovial membrane, fat and muscle tissues were taken 6 hours or f hours after Voltaren SR administration.<BR>(1) The concentration of diclofenac in the synovial fluid was higher than that of the serum.<BR>(2) The higher concentration of diclofenac in the synovial fluid compared to that of serum lasted for at least 12 hours after administration.<BR>(3) The concentration of diclofenac in the synovial membrane was higher than that in fat and muscle tissues.<BR>These results show that Voltaren. SR capsule has a good distribution to the synovial membrane and synovial fluid, and that it remains there for at least 12 hours.
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