Novel evaluation method of drug induced gastropathy using endoscopic sprayed drug delivery system.

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The effect of direct irritant action of anti-inflammatory powder drugs (about 2.5mg/kg) in canine gastric mucosa studied using an endoscopic compressed air drug delivery system technique. Aspirin and loxoprofen sodium induced mucosal lesions were limited to the target site of gastric mucosa in all dogs. Indomethacin (30%) and diclofenac Na (40%) induced superficial gastritis at the pyloric antrum, but did not appear to spray sites. Mefenamic acid, ketoprofen and proglumetacin maleate did not induced mucosal lesions. Predonisolone caused the erosion and edema throughout the stomach. No lesions were induced by lactose and sucralfate.<BR>In the present study, we could observe the experimental gastric mucosal lesion at the target site of the gastric mucosa by an administration of a small amount of powdered drugs via an endoscope. The administration of powdered drugs by endoscopy is useful for the investigation of direct effects of those on the gastric mucosa.
日本炎症・再生医学会の論文