Effect of Sho-seiryu-to and Saiboku-to on arachidonic acid metabolism by cultured porcine tracheal smooth muscle cells.
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概要
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We studied the effect of Sho-seiryu-to and Saiboku-to on arachidonic acid metabolism by cultured porcine tracheal smooth muscle cells. HPLC analysis revealed that both cyclooxygenase derivatives, especially PGE<SUB>2</SUB>, and lipoxygenase derivatives released in the culture medium were increased during 24-hour incubation of the tracheal smooth muscle cells with 1, 000μg/ml of Sho-seiryu-to. In contrast, the incubation of the tracheal smooth muscle cells with 1, 000μg/ml of Saiboku-to decreased both cyclooxygenase and lipoxygenase derivatives released in the culture medium. Increased release of PGE<SUB>2</SUB>from tracheal smooth muscle cells incubated with Sho-seiryu-to may support the therapeutic benefit for bronchial asthma because of broncho-dilatation effect by PGE<SUB>2</SUB>, and the suppression of the production of arachidonic acid metabolites by Saiboku-to may show the antiinflammatory action of Saiboku-to.
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