Study on the mechanism of peptide leukotriene production in rat liver.
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概要
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We have examined the mechanism of peptide leukotriene (LT) production in rat liver. LTC<SUB>4</SUB> synthesizing activity was shown to be localized in hepatocyte rather than non-parenchymal cells including Kupffer cell. Stimulation of the isolated hepatocyte with calcium ionophore (A 23187) did not cause any production of peptide LTs, whereas addition of LTA<SUB>4</SUB>induced a remarkable production of peptide LTs without the A 23187 stimulation. Kupffer cell which was shown to generate only a slight amount of peptide LTs with the A 23187 stimulation even in the presence of LTA<SUB>4</SUB>, produced remarkably peptide LTs when LTC<SUB>4</SUB>synthase partially purified from the hepatocyte was included into the culture system. Coculture of hepatocyte markedly enhanced production of peptide LTs.<BR>These results indicate that an enzymatic cooperation between hepatocyte and Kupffer cell would play an important role in generating peptide LTs in rat liver.
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