Long-term bucillamine administration in rheumatoid arthritis ; results of 5-year administration and prediction of its efficacy at initiation of treatment.

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This study had two purposes; to assess the results of 5-year administration of bucillamine (Bc), and to see the predictability of the continuous effect of Bc over 5 years on the basis of the clinical results obtained at the initial stage of administration. 68 patients with rheumatoid arthritis on Bc therapy from 1982 until 1985 were adopted as subjects. They consisted of 10 males and 58 females, with a mean age of 51.8±9.6 years and a mean disease duration of 9.2±8.2 years. Changes of Lansbury index were monitored, and the following results were obtained. 1) Bc was administered throughout 5 years in 14 patients (20.6%), Bc was discontinued in less than 5 years because of attenuation of effect in 8 patients (11.8%), because of absence of effect in 12 patients (17.6%), because of side effects in 16 patients (23.5%), and 18 patients (26.5%) dropped out of the study. 2) In patients who received Bc for 5 years, the Lansbury index improved significantly after 1 month of administration. This improvement was sustained over 5 years. 3) In patients who were withdrawn because of attenuation of effect, no improvement of Lansbury index was seen after 18 months of administration. 4) In patients who received Bc continuously over 5 years, the Lansbury index at month 18 demonstrated significant decrease below 55% of the level of the Lansbury index at the start of treatment. 5) In patients who received Bc continuously over 5 years and those who were withdrawn because of attenuation of effect, the Lansbury index decreased significantly below 90% of the initial value at month 1 and below 85% of that at month 2. However, in patients who were withdrawn because of absence of effect, no improvement of the Lansbury index was noted at either point. Based on these results, the following conclusions may be drawn. The efficacy of Bc lasts for a long period in about 20% of patients. Unless the Lansbury index decrease below 90% of the initial value at month 1 and below 85% at month 2, Bc cannot be expected to be effective. Furthermore, unless the Lansbury index at month 18 decrease below 55% of the initial value, its effect will not be maintained over 5 years.
日本炎症・再生医学会の論文

Long-term bucillamine administration in rheumatoid arthritis ; results of 5-year administration and prediction of its efficacy at initiation of treatment.

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日本炎症・再生医学会 | 論文

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