Changes in active oxygen generation by acidic non-steroidal anti-inflammatory drugs.
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Effect of acidic non-steroidal anti-inflammatory drugs (NSAIDs), indomethacin, floctafenine and tiaprofenic acid, on active oxygen generation from guinea pig peritoneal (GPtPMN) and human peripheral neutrophils (HPPMN) were studied. NSAIDs suppressed formylmethionyl-leucyl-phenylalanine (FM LP) -induced active oxygen generation from GPtPMN.<BR>Granulocyte colony-stimulating factor (G-CSF) enhanced receptor-mediated O<SUP>-</SUP><SUB>2</SUB> generation. Such a priming effect was closely correlated with proteintyrosyl phosphorylation of specific HPPMN proteins. NSAIDs also suppressed both the priming effect and the protein-tyrosyl phosphorylation by G-CSF in concentration dependent manners, and the effective concentrations were lower than those for the active oxigen generation from GPtPMN.<BR>These results suggest that NSAIDs effect not only an activation step (s) of NADPH-oxidase but also an early step (s) of neutrophils activation.
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