The antifungal and antibacterial activity of anti-ulcer terpens and sofalcone.
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概要
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The antifungal and antibacterial activity of both anti-ulcer terpens and sofalcone<I>in vitro</I>were studied.<BR>Among them, plaunotol has proved to show the strongest antibacterial and antifungal activity. It exhibits a wide spectrum activity against dermatophytes and Gram positive bacterias. The weak<I>in vitro</I>activity of sofalcone against dermatophytes and Gram positive bacterias was recognized and also gefarnate revealed the clinically useful MIC values, whereas teprenone didn't indicate antifungal and antibacterial activity<I>in vitro.</I><BR>Mechanism of fungicidal action is not clear, but present study suggests that surplus C<SUB>20</SUB>unit inhibits the transport of several glycoprotein of cytoplasm and/or metabolites of plaunotol having aldehyde may inhibit the growth of various dermaphytes and bacterias. These results indicate that anti-ulcer terpens and sofalcone may be useful for the treatment of superficial fungal infections.
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