Effect of cyclophosphamide intermittent-large dose-injection (CPA pulse therapy) on monocrotaline-induced interstitial pneumonia of rats.

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A single injection of monocrotaline (MCT) in rats, 60 mg/kg, could consistantly cause interstitial pneumonia 3-4 weeks after the injection. A preventive effect of cyclophosphamide, injected 4 times at 20 mg/kg each, on the rat pneumonia was studied in counting the 5-bromodeoxyuridine (BrdU) positive cells in the lung and measuring IL-1 and TNF levels in the culture supernatants of the bronchoalveolar lavage fluid (BALF) cells in the rats.<BR>The CPA pulse therapy suppressed significantly the proliferation of BrdU positive cells in the lung and the levels of IL-1 (P<0.001) and TNF (P<0.001) in the cultured BALF cells. It was suggested that macrophage and their products, IL-1 and TNF, would participate to the MCT-induced interstitial pneumonia of the rats and CPA could suppress the function of the macrophage.
日本炎症・再生医学会の論文