Endotoxin-induced acute lung injury in guinea pigs.

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We investigated parameters of acute lung injury and white blood cell kinetics following intravenous injection of 2 mg/kg endotoxin (ETX) in guinea pigs. We sacrificed the animals at 1, 2, 4, and 6 hours after ETX administration (1 hour group, 2 hour group, 4 hour group and 6 hour group, respectively) . We also had control group which was sacrificed at time 0 without ETX injection. 125I-albumin lung tissue to plasma ratio (T/P), 125I-albumin broncho-alveolar lavage (BAL) fluid to plasma ratio (B/P) and lung wet-dry weight ratio (W/D) were estimated to assess capillary endothelial permeability, alveolar septal permeability and pulmonary edema, respectively. T/P was increased in 1, 2 and 4 hour groups as compared with the control group. B/P did not increase in any of the EXT-treated groups as com-pared with the control group, whereas W/D increased in 1, 4 and 6 hour groups. Peripheral white blood cells decreased in every ETX-treated group. Cell count in BAL fluid increased only in 6 hour group as compared with the control group.
日本炎症・再生医学会の論文