Effect of Syosaiko-to on arachidonic acid metabolism of porcine pulmonary artery endothelial cells.
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Effect of Syosaiko-to, the boiling extract of a mixture of 7herbs, on arachidonic acid metabolism was examined by using porcine pulmonary artery endo-thelial cells in culture (PPAEC) . Both cyclooxyge-nase derivatives, including 6-keto-PGF 1α, and li-poxygenase derivatives released into cullture medium, were decreased during 24 hour-incubation with 500 μg/m<I>l</I> of Syosaiko-to by HPLC analysis. The decrease in thromboxane B<SUB>2</SUB> and lipoxygenase derivatives, 5-HETE, 12-HETE and 15-HETE, was more remarkable than that in 6-keto-PGF 1α. Thrombin-or bradykinin-stimulated PGI<SUB>2</SUB> production by PPAEC monolayer, however, was increased after 24 hour-incubation with Syosaiko-to, compared with control.<BR>Our experimental results show that Syosaiko-to suppresses the production of arachidonic acid meta-bolites, especially thromboxane B<SUB>2</SUB> and lipoxygenase derivatives, by PPAEC, supporting the antiinflamma-tory action of Syosaiko-to.
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