Role of pulmonary intravascular macrophages activation in increased pulmonary microvascular permeability.

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Pulmonary intravascular macrophages reside in the alveolar capillaries of sheep lung. We tested the effects of pulmonary intravascular mcrophages activation on pulmonary microvascular permeability.<BR>Sheep were divided into 3 groups; latex group, indomethacin group and OKY-046 (thromboxane A2 synthetase inhibitor) group. In each group, we infused latex beads emulsion, 1 μm in diameter, 5.46×10<SUP>10</SUP> beads/kg, intraarterially. In latex group, lymph protein clearance increased significantly during and after the infusion period. In indomethacin group, increases in lymph protein clearance were blocked completely. However, in OKY-046 group, lymph protein clearance increased significantly 3 hours after the infusion period. In each group, peripheral white blood cell counts decreased significantly during the infusion period, and recovered to the baseline valeus after the infusion. Many latex beads were caught by pulmonary intrvascular macrophages selectively.<BR>These results suggest that pulmonary intravascular macrophages activation through their phagocytic uptake of microparticles is essential to increase in pulmonary microvascular permeability in sheep.
日本炎症・再生医学会の論文