<I>Study on the relation between plasma prekallikrein (kallikrein) and protease inhibitors</I>
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概要
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I measured serum protease inhibitors, α<SUB>l</SUB>-antitrypsin, α<SUB>l</SUB>-antichymotrypsin, α<SUB>2</SUB>-macroglobulin, C 1 inactivator and inter-alpha-trypsin inhibitor by single radial immunodiffusion. I studied 15 normal controls and 52 patients with Behcet's disease.<BR>In serum α<SUB>l</SUB>-antitrypsin, α<SUB>l</SUB>-antichymotrypsis, and inter-alpha-trypsin inhibitor showed an increase over normal controls, but the other protease inhibitors showed sligh increase.<BR>A chromogenic sythetic tripeptide (Chrozym PK) was used as a substrate for kallikrein.<BR>There was a tendency to low plasma kallikreinin in Behcet's disease. There was no correlation between plasma prekallikrein and CRP. The values of plasma kallikrein/ prekallikrein showed a sharp rise as plasma C 1 inactivator level was over about 40 mg/d<I>l</I>.
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