<I>Improved efficacy in cardiomyocyte transplantation for myocardial infarction therapy through prevascularization induced by controlled release of basic fibroblast growth factor</I>

概要

論文の詳細を見る
Recently, several studies have demonstrated feasibility of cell transplantation for the therapy of failing heart. However, little has been considered for blood supply indispensable to cell transplantation. This study is an investigation to evaluate the feasibility of in advance angiogenesis by gelatin microspheres incorporating basic fibroblast growth factor (bFGF) for cell therapy of cardiomyocytes with an ischemic cardiomyopathy model. Our previous study revealed that the gelatin microspheres achieved controlled release of bFGF. Rats with myocardial infarction received the intramuscular injection of culture medium (Control), fetal cardiomyocytes (TX), gelatin microspheres incorporating bFGF (FGF), and gelatin microspheres incorporating bFGF followed by that of fetal cardiomyocytes 1 week later (FGF-TX) . Left ventricle (LV) function of rat hearts was assessed by echocardiography and cardiac catheterization 4 week later. The TX, FGF, and FGF-TX groups showed better fractional shortening than the Control group. LV maximum timevarying elastance was significantly higher in the FGF-TX group than other groups. These results indicate that the combination of bFGF-induced angiogenesis and cardiomyocyte transplantation is a promising procedure to improve the LV function in rats with myocardial infarction.
日本炎症・再生医学会の論文