<I>Cross-sectional analysis of NSAID-related gastrointestinal injury in patients with RA</I>:<I>A study using GI score questionnaire</I>

概要

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To investigate the prevalence of NSAID-related gastrointestinal (GI) complication in patients with rheumatoid arthritis (RA), a cross-sectional analysis was investigated using GI score questionnaire which has been used in the USA as a part of ARAMIS (Arthritis Rheumatism and Aging Medical Information system) . All patients taking NSAID who visited the Institute of Rheumatology, Tokyo Women's Medical University in October, 1999 were requested to answer the questionnaire. The number of patients taking NSAID was 31.4% of all patients who visited the Institute in the month. Analysis of RA patients who has been taking NSAIDs revealed that 31.5% had GI symptoms, 7.2% had histories of having diagnosis of GI ulcer and 1.8% had history of hospitalization due to GI injury. Prevalence of GI ulcer was high in those who were aged or were poor in general condition. These data suggest that the prevalence of NSAID-related GI complication is not few in Japan. In addition, the SCORE point was higher in patients with RA compared with non-RA patients, showing that the RA patients have higher risk for NSAID-related GI complication. However, no difference in the average SCORE point was noted in the class of NSAID. Thus, NSAID use acoording to the risk of each patients were necessary to be instructed.
日本炎症・再生医学会の論文