VIROLOGICAL AND PATHOLOGICAL STUDIES ON NEWBORN MICE EXPERIMENTALLY INFECTED WITH COXSACKIEVIRUS A16

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Virological and pathological studies were performed on newborn mice which had been infected experimentally with Coxsackievirus A16 and sacrificed serially every day.Virus titers began to increase in skeletal muscles on the 3rd day after virus inoculation and became remarkably high on the 4th and 5th days. They increased little in the heart muscle on the 4th and 5th days, but not at all in any other organ or tissue examined, i. e., liver, spleen, kidney, pancreas, brain, or thymus.Pathological changes were remarkable in the striated skeletal muscles especially on the 3rd and 4th days postinfection. Electron microscopic studies revealed the breakage of muscle bands and the increase of membranous systems in the cytoplasm. Slight changes were also found in the heart muscle but no changes at all in any other organ or tissue.
日本ウイルス学会の論文