STUDIES ON THE MURINE CYTOMEGALOVIRUS INFECTION:VIRAL GROWTH AND HISTOPATHOLOGICAL CHANGES IN THE CENTRAL NERVOUS SYSTEM
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概要
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This is the preliminary report of the experimental infection in central nervous system of mouse with murine cytomegalovirus.In the present study, newborn mice were inoculated intracerebrally with the Smith strain of murine cytomegolovirus. The infected mice were then studied clinically, virologically and histopathologically in comparison with the control mice inoculated with phosphate buffered saline.The results obtained were briefly as follows.1. Four deaths occurred in 31 infected mice between 10 days and 9 weeks inoculation, while none occurred in 15 non-infected mice.2. Viruria was observed on the 2nd and 3rd day of infection and ceased thereafter.3. Virus recoveries from the brain were possible after the third day of infection. Infective titers in 10 per cent brain homogenates were maximum at the 4th day, gradually decreased and became negative after 21th day of infection.4. The infected mice generally showed under-development of body weight, dull movement and lusterless fur. These symptoms were observed obviously 2 weeks after infection, at the stage when the histopathological changes in the brain were prominent. Convulsions and ataxia were observed only in the two cases of death.5. Histopathological change of the brain was appropriate for localized encephalitis. Cytomegalic change with intranuclear inclusion body was observed in the population of nerve cells in the basilar region of the brain and in Purkinje's cells of cerebellum. Lymphoid cell infiltration was observed in a slight degree.
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