STUDIES ON SEVERAL INHIBITORS AGAINST INFIUENZA VIRUS, 6TH REPORT:CHARACTERIZATION OF NON-SPECIFIC HEMAGGLUTININ INHIBITORS DETECTABLE IN EXPERIMENTAL ANIMALS
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Sera obtained from normal guinea pigs, rabbits, chickens and monkeys were examined to characterize the non-specific hemaggultinin inhibitors contained in each. Although preliminary results on this p problem were previously described, reexamination was thought to be necessary after a discovery of the avid Asian virus. High sensitivity of this virus to various inhibitors, again made this problem as an unsettled one.In the study, both heated Lee and Asian P viruses were used to see the different distribution of a and a inhibitors in these sera. Mumps, Sendai and Newcastle disease viruses were also used to characterize each inhibitor, because these hemolytic viruses were known to form irreversible union with red cells, like Asian P virus.Obtained results will be summarized as follows:1) a-inhibitor noticed in guinea pig sera by Shimizu and Ishida using FMI strain of influenza A virus as an indicator, was shown to be the same principle active against Asian set of P virus. This principle was different from a-inhibitor active against heated Lee.2) An inhibitor specifically active against mumps virus was found in monkey sera of both rhesus and cynomologous. Furthermore, with serum specimens obtained from animals other than monkey, inhibitor titer against heated Lee virus.3) Newcastle disease virus was found to be more sensitive to serum specimens received pretreatment of either RDE or KIO4 than that without any treatment. This kind of change was particularly the case with monkey and guinea pig sera, and was assumed to be the same phenomenon as reported as the heat activation phenomenon.
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