STUDIES ON TRANSMISSION OF ANTIBODY AGAINST JAPANESE ENCEPHALITIS VIRUS FROM MOTHER TO HER NEW BORN RATS
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概要
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The attempt was made to follow up how the antibodies, mainly neutralizing antibody and partly hemagglutination inhibiting antibody do pass from the mother onto her new born rats in the experiments, (1) active immunization with living virus, (2) passive immunization with homologous immune rat serum during the later half of pregnancy as well as after the birth, (3) cross lactation test between the immunized mother rat and her new born and the normal mother rat and her new born (4) oral adminsistration with homologous immune rat serum in the new born from the normal mother rat. The results were obtained as follows:1) Neutralizing and hemagglutination inhibiting antibodies were detected in sera both from the pregnant rats immunized actively and passively respectively.2) The titer of neutralizing antibody in the new born which might be transfered through the placenta from the immunized mother is less than those in the mother rat.3) when the new born from the immunized mother are lactated from the norma 1 mother rat their neutralizing antibody will disappear gfadually in 40 to 50 days after the birth, 4) Both neutralizing and hemagglutination inhibiting antibodies are transfered through lactation from the immunized mother rats onto the new born from the normal rat. Their titers are the same or nearly the same to those of their mothers. The antibodies in the now born which was transfered passively through lactation would disappear parallel to those of the passively immunized mother or after the weaning from the actively immunized mother which are still positve in antibodies.5) No significantly positive reaults were obtained to find both neutralizing and hemagglutination inhibiting antibodies in the sera of the new born following oral administration of homologous immune rat serum. The results are, however, suggested that the antibodies might pass through the oral route onto the new born rats.
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日本ウイルス学会 | 論文
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