STUDIES ON THE CHANGES OF BLOOD INGREDIENTS AND BLOOD PRESSURE FOLLOWING MASSIVE, RAPID BLOOD TRANSFUSION
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In 33 mongrel dogs, the author investigated the change of some blood ingredients and blood pressure in groups as divided according to rapid excessive, slow excessive, large hemorrhage-replacement blood transfusion and to mechanical heart and lungs.1) The changes generally observed in these experiments consisted of hemoconcentration and significant decrease of the solid constituents of blood and impairment of hepatic functions.2) The circulating blood and plasma volume and hematocrit values were increased with excessive blood infusion, unless associated with liver disturbances. But the volume by which the blood in circulation was increased was less than the volume of the infused blood, probably because various compensatory mechanisms or the mechanism of extravasation were operating in the congested body. Hematocrit was increased in proportion to the speed of infusion rather than to the volume.3) The plasma protein was increased in value over the corresponding protein infused, the protein fractions showing a reduction in the A:G ratio, without giving any sign of extravasation.4) Of the formed elements of blood, the red blood cells were increased in number, though less in number than that of infusion, in those cases in which the method of infusion used caused serious mechanical impairment. The white blood cells and platelets were remarkably decreased in number.5) The other changes inevitably produced in any massive transfusion were prolonged thrombin time, reduced pH of blood, and fibrinopenic condition.6) Liver impairment, hemorrhagic tendency and other disorders produced are all curable sooner or later unless there are some complications, such a s liver disturbance developing previously. Transfusion in the presence of liver impairment and the effect of ACD as a preservative were reevaluated.
- 一般社団法人 日本輸血・細胞治療学会の論文
一般社団法人 日本輸血・細胞治療学会 | 論文
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