EXPERIMENTAL PATHOLOGICAL STUDIES ON EDTA-Ca THERAPEUTICAL EFFECT IN HABU-BITE LESION
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概要
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Habu's (<I>Trimeiesurus flavoviridis</I>) bite shows two main local morbid changes : Hemorrhage caused by the venom and necrosis of the muscles. By animal experiments we discovered that these morbid changes were nothing but a digestive action of proteinase, which was contained in the venom of, Habu. We, the members of the Pathological and Microbiological Institutes, also made it clear that this proteinase-activity could be prevented when we cheleted Mm·· with EDTA, which is a component of this enzyme.<BR>I have tried a therapeutical experiment of Habu venom in animal, using EDTA-Ca as cheleting substance.<BR>Experimental animals (guinea-pigs) were given 0.5mg (dry weight) venom subcutaneously. Immediately after the injection, EDTA-Ca was injected by incision. Hemorrhagic necrosis (a characteristic venomous effect of Habu venom) was repressed.<BR>It is true that antivenom serum therapy is quite effective for Habu venom therapy, but when this therapy is not available in the places like mountain sides or fields where the bites often occur (and that is the case we often meet), it would be advisable to take this compound as first-aid in the Habu-prevailing districts.
- 北関東医学会の論文
北関東医学会 | 論文
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