THE POSSIBLE ROLE OF INTRAVENTRICULAR ARGININE VASOPRESSIN IN INTRACEREBEAL ANTINOCICEPTIVE MECHANISM IN MONKEY
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The role of the neurohypophysial peptide hormone arginine vasopressin (AVP), which is thought to be involved in intracerebral antinociceptive mechanism of pituitary neuroadenolysis (NALP), was examined in non restrained adult male Japanese monkeys. The effect of intraventricular administration of AVP on somatosensory evoked potentials (SSEPs) elicited by stimulation of the median nerve and on the total urine output over a 2 hr period were measured.<BR>The results were compared with those obtained by using fentanyl and U-50, 488H. AVP, fentanyl and U-50, 488H only prolonged the late-component latencies of SSEPs, and did not alter short-component latencies. Opioid antagonists, such as naloxone and MR-2266BS, had no effect. AVP reduced the urine output.<BR>D (CH<SUB>2</SUB>) <SUB>5</SUB>, Tyr (Me) -AVP (AAVP), a potent V<SUB>1</SUB> vasopressin receptor selective antagonist abolished this AVP-evoked response, but opioid antagonists such as naloxone and MR-2266BS had no effect. The present results support our conclusions that the analgesic effect of AVP on the development of antinociception in monkey is the result of its direct or indirect physiological role in non-opioid pain inhibitory systems via V<SUB>1</SUB> receptors.
- 北関東医学会の論文
北関東医学会 | 論文
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