URINARY EXCRETIONS OF GUANIDINOACETIC ACID, β<SUB>2</SUB>-MICROGLOBULIN, AND N-ACETYL-β-D-GLUCOSAMINIDASE IN NEONATES
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Urinary excretions of guanidinoacetic acid (GAA), β<SUB>2</SUB>-microglobulin (β<SUB>2</SUB>MG), and N-acetyl -β-D-glucosaminidase (NAG) are putative parameters of proximal tubular functions. In this study, I investigated the effect of age on these parameters in newborn infants. Urinary samples (N = 97) from 25 fullterm infants and 6 preterm infants without serious complications were studied. Urinary concentrations of GAA, β<SUB>2</SUB>MG, and NAG activity, as well as creatinine (Cr), were measured in each sample. The ratio of urinary GAA to Cr (U-GAA/Cr ; mg/g) in the neonates ranged from 4.6 to 440.0 mg/g (mean±SD, 111.76±78.90 mg/g). U-GAA/Cr in healthy adults was 67.1±32.1 mg/g. U-GAA/Cr had a positive correlation with postnatal age (r =0.33, p<0.001) and with postconceptional age (r =0.43, p<0.001).<BR>In contrast, the ratios of urinary β<SUB>2</SUB>MG to Cr (U-β<SUB>2</SUB>MG/Cr ; mg/g) and U-NAG/Cr (U/g) had negative correlations with postconceptional age, but not with postnatal age. U-GAA/Cr correlated with neither U-β<SUB>2</SUB>MG/Cr nor with U-NAG/Cr.<BR>We speculate that U-GAA/Cr might reflect proximal tubular function, in a manner different from that of urinary β<SUB>2</SUB>MG and urinary NAG activity.
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