ENZYMOLOGICAL STUDY OF MNNG-INDUCED GASTRIC CARCINOMA IN RATS
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In this study, the effects of MNNG administration on alteration of the LDH isoenzyme pattern and activity level of alkaline phosphatase in gastric mucosae during carcinogenesis were investigated in a rat model.<BR>The following results were as obtained : <BR>1) In the MNNG-induced gastric cancer bearing animals, LDH<SUB>5</SUB> and alkaline phosphatase values were significantly higher in gastric cancer tissue than in normal gastric mucosa.<BR>2) During carcinogenesis, LDH<SUB>5</SUB> value rose in 20-week-old rats to which MNNG had been administered. It was significantly higher (P < 0.01) in MNNG-administered 40-week-old rats than in control animals.<BR>3) These data suggested that anaerobic metabolism of glucose in the gastric mucosa was activated prior to the macroscopic detection of carcinoma in MNNG treated rats.
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北関東医学会 | 論文
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