A NOVEL IL-5 AND IL-6 SENSITIVE PLASMACYTOMA CLONE, MD90
スポンサーリンク
概要
- 論文の詳細を見る
MD90, a factor-dependent clone derived from an in vitro-adapted murine plasmacytoma parent cell line, proliferated in respose to murine and human interleukin (IL) -6, but not murine IL-1β, IL-2, IL-3, IL-4, IL-7, interferon (IFN) -γ, tumor necrosis factor (TNF) -α, granulocyte/macrophage-colony stimulating factor (GM-CSF), or lipopolysaccharide (LPS). IL-5 also promoted the proliferation of MD90 cells but to a much lesser extent. Anti-IL-5 monoclonal antibodies inhibited the proliferation of MD90 cells in response to IL-5 but not to IL-6. Anti-IL-6 monoclonal antibodies inhibited the proliferation of MD90 cells in response to IL-6 but not to IL-5. These results confirm the novel specificity of MD90 and demonstrate that MD 90 cells are directly responsive to IL-5 and IL-6. These data indicate that MD90 cells can serve as a simple bioassay for IL-5 /IL-6 and can be made monospecific for IL-5 or IL-6 using anti-IL-5 or anti-IL-6.
- 北関東医学会の論文
北関東医学会 | 論文
- 12. PCTが行う緩和ケア外来―利根中央病院の経験―(第18回群馬緩和医療研究会)
- P-4.患者が「死にたい」とロにしたとき : 当院緩和ケアチームにおける精神科医の役割から見えたもの(パネルディスカッション,第15回群馬緩和医療研究会)
- 23.一般病棟でおこなう緩和ケア(心理的なケア)とは何か : いち臨床心理士から見えたもの(一般演題,第15回群馬緩和医療研究会)
- 19.医療者がケアの視点をもつことの意味(一般演題,第15回群馬緩和医療研究会)
- 11.終末期患者の食事摂取をめぐる倫理的葛藤(一般演題,第15回群馬緩和医療研究会)