SHOCK INDUCED RECOMBINANT TUMOR NECROSIS FACTOR AND ITS PREVENTION IN THE RAT
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概要
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Tumor necrosis factor (TNF) has been implicated as a mediator of endotoxemia. Mean lethal dose was estimated to be 1.47 mg of recombinant human TNF per kilogram of body weight. The endotoxin content of this TNF was less than 0.2 ng per milligram of protein. A 2 mg dose of TNF caused metabolic acidosis and hemoconcentration. Release of lysosomal enzyme and hyperkalemia was observed. The cyclooxygenase inhibitor indomethacin and platelet activating factor antagonist CV-3998 given before TNF treatment prevented death at five hours. These agents prevented metabolic acidosis, hemoconcentration, release of lysosomal enzyme and hyperkalemia. Since similar physiological changes have been reported after endotoxin injection, our data support the suggestion that TNF production is a critical factor in the development of septic shock. These findings indicate that increased production of prostaglandins and platelet activating factor is important in TNF shock.
- 北関東医学会の論文
北関東医学会 | 論文
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