AUTORADIOGRAPHIC STUDY OF DIGESTIVE TRACT CARCINOGENESIS INDUCED BY N-METHYL-N'-NITRO-N-NITROSOGUANIDINE (MNNG) IN RAT:COMPARATIVE STUDY ON CELL KINETICS OF STOMACH, SMALL INTESTINE AND COLON

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Various mucosal changes of the digestive tract induced by 75 mg/l MNNG plus 3 g/l Tween-60 dissolved into tap water in Wistar female rats were autoradiographically and histologically studied, and the following results were obtained.<BR>1) The incidence of the tumor in rats administered orally for more than 10 months was 47% in the stomach and 73% in the small intestine.<BR>2) The number of labeled cells (NLC) in 6-week-aged normal rats was 100 in the small intestine, 26.6 in the pyloric gland, 20.6 in the oxyntic gland and 12.6 in the colon. Tumors were frequently found in the small intestine and pyloric gland showing higher NLC by administration of MNNG.<BR>3) Increases of NLC and positive NLC-a were found in the mucosa of the pyloric gland and small intestine 6 months after administration of MNNG, and epithelial tumor, descending adenomatous hyperplasia and sarcoma developed 10 months after administration.<BR>4) Autoradiographically, cells of the proliferative zone in the lower half of mucosae of normal pyloric gland and small intestine were labeled in a regular manner, while labeled cells in the regenerative mucosa induced by administration of MNNG were found near the luminal surface.
北関東医学会の論文