EFFECT OF 1 α-HYDROXYVITAMIN D<SUB>3</SUB> ON 7, 12-DIMETHYLBENZ (A) ANTHRACENE-INDUCED RAT MAMMARY TUMORS
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We studied the antitumor effect of activated vitamin D<SUB>3</SUB>, which is reported to have a proliferation inhibitory action in vitro against several strains of breast cancer cells in vivo using 7, 12-dimethylbenz (a) anthracene (DMBA) -induced rat mammary tumors.<BR>After mammary tumors developed as a result of administration of 20 mg of DMBA to 6-week-old female Sprague-Dawlay (SD) rats, we conducted daily oral administration of 1α-hydroxyvitamin D<SUB>3</SUB> (1α (OH) D<SUB>3</SUB>) for 4 weeks in a dose of 0.02, 0.1, 0.5 and 1μg/kg. Every week tumor size and body weight were measured, and after 4 weeks the estrogen receptors (ER) of the tumor and serum Ca concentration were determined. Moreover., we compared the rate of change in tumor size when each of the 3 drugs, 5-FU, Medroxyprogesterone acetate (MPA) and Tamoxifen (TAM) was administered alone or in combination with 1α (OH) D<SUB>3</SUB>.<BR>The results showed that 1α (OH) D<SUB>3</SUB> suppresses the growth of DMBA-induced rat mammary tumors dose-dependently. In combination with 5-FU, potentiation of the antitumor action was suggested, but in combination with MPA and TAM, no potentiation was observed.
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北関東医学会 | 論文
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