A CASE OF HYDROCORTISONE SODIUM SUCCINATE-INDUCED ASTHMA
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概要
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This is a report of a 62-year-old man with a history of asthmatic attack following therapy for bronchial asthma with intravenous injection of hydrocortisone sodium succinate (Saxizon<SUP>®</SUP>, Solu-Cortef<SUP>®</SUP>).He had had episodes of dyspnea since 1979 and was treated with oral bronchodilators and intermittent cortimosteroids (prednisolone), and at the exacerbation of asthmatic symptoms he was treated with intravenous drip infusion containing aminophylline and Saxizon<SUP>®</SUP>. On June 15, 1983, he complained of dyspnea. As a result, he was given 200mg of Saxizon<SUP>®</SUP> intravenously. After then, his asthmatic attack worsened. To confirm the suspected relationship between the drugs and asthmatic attack, intravenous provocative challenge tests were performed, and 100mg of Saxizon<SUP>®</SUP> and Solu-Cortef<SUP>®</SUP> revealed positive results, but intravenous challenge tests with 100mg of hydrocortisone disodium phosphate (Hydrocortone<SUP>®</SUP>) and 20mg of prednisolone sodium succinate (Predonine<SUP>®</SUP>, Shionogi) and oral challenge with 100mg of hydrocortisone (Hydrocortone<SUP>®</SUP>, Japan Merck-Banyu) were negative. Skin and P-K tests with hydrocortisone sodium succinate were positive. Although this type of adverse reaction to steroidal products is rare, it is very important in allergy practice.
- 北関東医学会の論文
北関東医学会 | 論文
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