IS LIPOPEROXIDATION PLAYING A SIGNIFICANT CAUSATIVE ROLE IN ADRIAMYCIN-INDUCED CARDIOMYOPATHY ?
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概要
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The purpose of this study is to determine whether the lipoperoxidation is playing a significant causative role in adramycin cardiomyopathy.<BR>Cardiac alterations with characteristic histologic changes such as vacuolizations of myocardial cells, myolysis and the interstitial fibrosis developped in rabbits when 2. 5 mg/kg of adriamycin was intravenously administered once a week for 8 weeks. Blood and cardiac malondialdehyde was significantly increased in these animals. Although daily administrations of 50 mg/kg of alpha tocopherol, a free radical scavenger, obviously suppressed the increase of blood and cardiac malondialdehyde, the development of cardiac lesions could not be prevented by this drug.<BR>The present observations may suggest that the lipoperoxidation is a result and not a cause of adriamycin cardiomyopathy.
- 北関東医学会の論文
北関東医学会 | 論文
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