A CASE OF THE BLADDER CANCER TREATED WITH CONTINUOUS INFUSION OF NK631 INTO THE INTERNAL ILIAC ARTERY

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The patient was a 70-year-old man who visited our hospital with the chief complaint of hematuria on November 21, 1977. He was performed partial cystectomy for the bladder tumor in 1970. The multiple tumors of the bladder were found on cystoscopy. Biopsy of the bladder showed transitional cell carcinoma, Grade I.<BR>After the paramedian incision the internal iliac artery was exposed extraperitoneally. At the same time, the superior gluteal artery was ligated. The cannula was inserted into the internal iliac artery. 5mg of NK631 was continuously infused via the cannula per day. 120mg of NK631 was infused via the cannula of the right side. After infusion of 60mg of NK631 via the cannula of the left side bleeding of the bladder occured. Infusion was stoped and blood transfusion of 2600ml was undergone. 90mg was medicated via the left cannula in all.<BR>Effects of continuous infusion were judged cystoscopically. The tumors of the right side disappeared or reduced remarkably. But the tumors of the left side were invariable. Side effects of infusion of NK631 were abdominal discomfort and alopetica. Afterward the patient was undergone TUR-Bt and bladder instillation of Adriamycin, Mitomycin C. The recurrence of the tumor has not occured up to the present December, 1979.
北関東医学会の論文