INCREASED PANCREATIC LECITHINASE-A ACTIVITY AND ITS CORRELATION TO ALVEOLAR STABILITY DURING SHOCK
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概要
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The objective of the present study was to investigate the role of pancreatic lecithinase-A released into systemic circulation during shock involving the deterioration of alveolar surface activity. Mongrel dogs were led to hemorrhagic shock maintaining mean arterial blood pressure 40 mmHg until 40% of shed blood was spontaneously taken up. Then remaining blood was retransfused and the experiment was terminated when arterial pressure declined to 50 mmHg. The changes of lecithinase-A and lysosomal hydrolases in the pancreas and plasma were observed every hour through the experement. Pulmonary surface activity was determined on excised lobes at the terminal stage after retransfusion. Next, the effect of lecithinase-A infused intraveously on arterial blood oxgenation and pulmonary stability was assessed on anesthetized dogs.<BR>The arterial blood oxygen tention decreased at the terminal stage following retransfusion in shocked animals. Plasma concentration of lecithinase-A increased markedly 120 minutes after the initiation of oligemic hypotention, being preceded by a rise in lecithin splitting enzyme of the pancreas. Pressure-volume curves of the excised lobes of dogs in hemorrhagic shock and lecithinase infusion showed significant shifts to the right, demonstrating the reduction in pulmonary surface activity. These results suggest that pancreatic lecithinase-A released into plasma may inactivates pulmonary surface active substances.
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北関東医学会 | 論文
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